Our analyses demonstrate that each epitope-specific repertoire contains a clustered group of receptors that share core sequence similarities, together with a dispersed set of diverse ‘outlier’ sequences. We developed analytical tools to characterize these epitope-specific repertoires: a distance measure on the space of TCRs that permits clustering and visualization, a robust repertoire diversity metric that accommodates the low number of paired public receptors observed when compared to single-chain analyses, and a distance-based classifier that can assign previously unobserved TCRs to characterized repertoires with robust sensitivity and specificity. Here we report the in-depth characterization of ten epitope-specific TCR repertoires of CD8 + T cells from mice and humans, representing over 4,600 in-frame single-cell-derived TCRαβ sequence pairs from 110 subjects. Despite this potential diversity, TCRs from T cells that recognize the same pMHC epitope often share conserved sequence features, suggesting that it may be possible to predictively model epitope specificity. TCRs are generated by genomic rearrangement of the germline TCR locus, a process termed V(D)J recombination, that has the potential to generate marked diversity of TCRs (estimated to range from 10 15 (ref. This isn't always a bad thing - I'm a big punk rock fan, and most of the classic punk repertoire is high-octane blocks of undifferentiated mood.įancy paints on memory's canvas/Scenes that we hold dear Matthew Guerrieri 2008Īnother item in the Mexican sandwich repertoire is the cemita (sometimes spelled 'semita') a popular regional treat in Central Mexico.Ī Meal in a Sandwich: Tortas, Cemitas, Pambazos 2008T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that mediates recognition of pathogen-associated epitopes through interactions with peptide and major histocompatibility complexes (pMHCs). The performing repertoire is getting smaller and smaller, to the point where we may need reminding that there is more to music than Mozart, Beethoven and, yes, Mahler. Karen Owen's Duke thesis may land her in a heap of trouble - and a lucrative book deal Melissa Bell 2010 When your entire college sexual repertoire is spread across the Internet for the world to read, it might be a disheartening experience.

The Lenten repertoire is not the same as the Easter repertoire or the Advent repertoire. New Orleans' Jazz Fest wraps up another stellar run 2010 Though the band's repertoire is largely instrumental, the new album features many guest vocalists, some who joined them for the show. It's all red-faced denials, rage, deflection, lies, stony silence - the entire repertoire is there.

noun a collection of works (plays, songs, operas, ballets) that an artist or company can perform and do perform for short intervals on a regular schedule.noun the entire range of skills or aptitudes or devices used in a particular field or occupation.A collection of items.įrom WordNet 3.0 Copyright 2006 by Princeton University. noun A set of skills possessed by a person.noun A list of dramas, operas, pieces, parts, etc., which a company or a person has rehearsed and is prepared to perform or display.noun A list of dramas, operas, pieces, parts, etc., which a company or a person has rehearsed and is prepared to perform.įrom Wiktionary, Creative Commons Attribution/Share-Alike License.noun A repertory specifically, in music and the drama, the list of works which a performer or company of performers has carefully studied, and is ready to perform.įrom the GNU version of the Collaborative International Dictionary of English.noun The range or number of skills, aptitudes, or special accomplishments of a particular person or group.

noun The class of compositions in a genre.noun The stock of songs, plays, operas, readings, or other pieces that a player or company is prepared to perform.From The American Heritage® Dictionary of the English Language, 5th Edition.

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